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An article published in the journal Nature reports on a new understanding of the growth of human stem cells. It had been thought previously that stem cells are directly influenced by cells in the local environment or 'niche', but the situation may be more complex. Human embryonic stem cells are perpetual machines that generate fuel for life. Researchers of the McMaster Cancer and Stem Cell Research Institute show that human embryonic stem (ES) cells can actually produce distinctive niche cells, which then release stem-cell nourishing proteins to help keep their 'parents' ticking over. Scientific Director Mick Bhatia and colleagues provide the first evidence that human ES cells have the unique ability to generate human-ES-cell-derived fibroblast-like niche cells (hdFs) in vitro despite removal from their in vivo microenvironment. These hdFs then provide a continuous source of supportive proteins, including insulin-like growth factor 2 (IGF-II), which they now show could be "the" protein to sustain hESCs..	¡@
	¡@	Illustration shows a human embryonic stem cell colony expressing insulin-like growth factor (IGF) receptors (red), surrounded by niche cells expressing fibroblast growth factor (FGF)receptors (green). Blue indicates the nucleus of all cells in the dish. (Credit: Image courtesy of McMaster University)

Researchers are interested in the relationship between stem cells and their niche, because the niche represents a route for modifying stem cell behaviour -- if human ES cells can be reliably guided down a particular pathway, then they can be more readily used for future clinical therapy to regenerate damaged tissue such as neurons for Parkinson's disease, or insulin producing cells for diabetes .

The research has been funded by the Canadian Institutes for Health Research and the National Cancer Institute of Canada.

The Nature article is the latest in a series of important papers published by scientists at the 18-month-old institute, which was established with funding by philanthropist Michael G. DeGroote. The institute has a research focus on the molecular determinants of cancer and tissue repair and is building scientific momentum.

"This discovery of a new fundamental understanding about how human stem cells develop is the kind of scientific work which has already put this Institute on the map as the leader in this field," said John Kelton, dean and vice-president of McMaster's Faculty of Health Sciences.

Mick Bhatia said that he and his scientific team have been working for the past year to prove themselves wrong, but as every test confirmed their discovery, it was time to submit the work for international peer review from other experts.
"This will be critical for future developments involving drug and gene screening of human ES cells, that will be required before clinical use of human stem cells of this kind," he said.

The paper will be published electronically on Nature's website on July 11, but will be published in print later this month.

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The paper will be published electronically on Nature’s website on July 11, but will be published in print later this month.

McMaster University, a world-renowned, research-intensive university, fosters a culture of innovation, and a commitment to discovery and learning in teaching, research and scholarship. Based in Hamilton, the University, one of only four Canadian universities to be listed on the Top 100 universities in the world, has a student population of more than 23,000, and an alumni population of more than 125,000 in 125 countries.
Editor’s note: available for downloading at http://www.fhs.mcmaster.ca/media.htm

• Colour pictures of human stem cells

• Short video of human stem cell development

• Graphic of how human stem cell develops niche cells which provide nourishment to stem cell

• Pictures of scientists of McMaster Stem Cell and Cancer Research Institute
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